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Labcoat omics reproducibility

Skill qchiujunhao/labcoat/skills/labcoat-omics-reproducibility

Reproducibility discipline for RNA-seq, scRNA-seq, ATAC-seq, variant, proteomics, imaging, Scanpy, Seurat, clustering, and omics pipeline work. Use when inputs, references, seeds, QC thresholds, layers, versions, or outputs affect scientific correctness.From its SKILL.md

Install
npx -y skills add qchiujunhao/labcoat --skill labcoat-omics-reproducibility

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SKILL.md

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Omics Reproducibility

Make omics code rerunnable and biologically interpretable.

Decision Ladder

  1. State input files, sample schema, units, organism, and genome/reference where relevant.
  2. State counts/layer assumptions and normalization.
  3. Set deterministic seeds for stochastic steps.
  4. Record QC thresholds and filtering scope.
  5. Define exact output files, columns, and smoke tests.

Allowed

  • Conservative checks that ask for missing build/species/layer/QC context.
  • Minimal pipeline smoke tests on synthetic data.
  • Version and parameter notes in code or docs.

Disallowed

  • Do not assume adata.X is raw counts.
  • Do not assume VCF normalization, FASTQ encoding, or coordinate build.
  • Do not silently change filtering scope.

Output

Use:

  • Inputs:
  • Assumptions:
  • Determinism:
  • QC:
  • Outputs:
  • Smoke test:

Read the checklist matching the omics domain.

What ships with it: 3 files

774 B alongside SKILL.md

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