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Trialgpt matching

Skill FridrichMethod/awesome-skills/skills/trialgpt-matching

Trial shortlistFrom its SKILL.md

Install
npx -y skills add FridrichMethod/awesome-skills --skill trialgpt-matching

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SKILL.md

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<!-- # COPYRIGHT NOTICE # This file is part of the "Universal Biomedical Skills" project. # Copyright (c) 2026 MD BABU MIA, PhD <[email protected]> # All Rights Reserved. # # This code is proprietary and confidential. # Unauthorized copying of this file, via any medium is strictly prohibited. # # Provenance: Authenticated by MD BABU MIA -->

TrialGPT Matching

Run the locally checked-out TrialGPT pipeline to retrieve, rank, and explain candidate trials for a patient before deeper eligibility review.

Inputs

  • Patient summary (structured JSON or free text) with condition keywords.
  • Optional filters: geography, phase, intervention, biomarker.
  • Up-to-date ClinicalTrials.gov dump or API access.

Outputs

  • Ranked trial table with NCT ID, title, score, and short justification.
  • Parsed inclusion/exclusion text ready for downstream eligibility agents.
  • Missing data checklist (e.g., "ECOG not provided").

Workflow

  1. Setup: cd repo && pip install -r requirements.txt (or reuse env).
  2. Trial retrieval: Run TrialGPT retriever to pull candidate trials for the indication.
  3. Criteria parsing: Convert eligibility blocks to structured criteria JSON.
  4. Patient profiling: Summarize patient facts (labs, prior therapies, biomarkers).
  5. Ranking: Execute TrialGPT ranking script to score each trial and emit explanations.
  6. Handoff: Export ranked list + structured criteria for trial-eligibility-agent.

Guardrails

  • Refresh ClinicalTrials.gov metadata regularly to avoid stale trials.
  • Label scores as AI-generated suggestions pending clinician validation.
  • Retain prompt/config metadata for audit trails.

References

  • Detailed usage instructions and repo layout live in README.md.
  • Coordinate with Skills/Clinical/Trial_Eligibility_Agent for criterion-level review.
<!-- AUTHOR_SIGNATURE: 9a7f3c2e-MD-BABU-MIA-2026-MSSM-SECURE -->

What ships with it: 12 files

41.7 KB alongside SKILL.md, 8 of them executable

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