MAGE
Skill FridrichMethod/awesome-skills/skills/antibody-design-agent/MAGE
Ab seq forgeFrom its SKILL.md
npx -y skills add FridrichMethod/awesome-skills --skill MAGEAssembled from the repository path, not quoted from the project. Check it against their README if it does not work.
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SKILL.md
1.7 KB, 305 tokens by cl100k_base, as published. Nobody here has run it
MAGE (Monoclonal Antibody Generator)
Run the MAGE antibody generation workflow to propose antigen-conditioned antibody sequences for downstream structural validation.
Workflow
- Prep env:
cd repoand install dependencies, then point to GPU if available. - Run generator:
python generate_antibodies.py --antigen_sequence <SEQ> --num_candidates N --output_dir ./results. - Collect outputs: Provide FASTA paths + metadata, optionally translate into JSON manifest.
- Recommend validation: Suggest AlphaFold/Rosetta checks and wet-lab follow-up.
Guardrails
- Never imply binding efficacy without structural/experimental confirmation.
- Track model version + seeds to ensure reproducibility.
- Encourage downstream filtering (liability motifs, developability metrics).
References
- Source instructions in
README.mdand repo scripts.
What ships with it: 36 files
7065.6 KB alongside SKILL.md, 2 of them executable
repo/
- Data cleaning/ASAb_database_metadata_v2_24-03-12.xlsx31.1 KB
- Data cleaning/CoVAbDab/covabdab_gen_curation_allBinders_allVariants_v2_24-03-12.ipynb41.1 KB
- Data cleaning/CoVAbDab/NTD_SA.npy550.5 KB
- Data cleaning/CoVAbDab/RBD_SA.npy329.7 KB
- Data cleaning/crowe_ebola/crowe_ebola_processing_24-03-07.ipynb7.1 KB
- Data cleaning/denovo_absci/denovo_trastuzamab_24-02-29.ipynb7.8 KB
- Data cleaning/final_processing/detagging_script_24-03-04.ipynb191.2 KB
- Data cleaning/final_processing/final_concat_v2_24-03-12.ipynb6.4 KB
- Data cleaning/flu_LLM_paper/wang_preprint_flu_cleaning_24-01-03.ipynb39.1 KB
- Data cleaning/Other_notebooks/10618/10618_antigen_alignment_v1_24-03-06.ipynb26.8 KB
- Data cleaning/Other_notebooks/10618/AA_10618_LLM-clean_24-03-06.ipynb35.6 KB
- Data cleaning/Other_notebooks/atlas_antigen_alignment_v1_24-03-04.ipynb10.8 KB
- Data cleaning/Other_notebooks/published_LIBRA-seq_concatenation_24-05-31.ipynb22.8 KB
- Data cleaning/Other_notebooks/SAbDab/detagging_script_24-03-04.ipynb233.5 KB
- Data cleaning/Other_notebooks/SAbDab/SAbDab_final_clean_v1_24-03-04.ipynb16.9 KB
- Data cleaning/Other_notebooks/signalP/detagging_nonSAbDab_24-03-12.ipynb26.2 KB
- Data cleaning/Other_notebooks/signalP/signalP_summary_output_24-03-12.txt6.2 KB
- Data cleaning/PlAbDab/ebola_Bornholdt_24-03-07.ipynb7.2 KB
- Data cleaning/PlAbDab/ebola_EhrHardt_24-01-03.ipynb65.5 KB
- Data cleaning/PlAbDab/gilman_RSV_24-01-04.ipynb8.9 KB
- Data cleaning/PlAbDab/hcv_24-01-03.ipynb3.2 KB
- Data cleaning/zurbuchen/zurbuchen_data_23-03-08.ipynb56.0 KB
- Fine_tuning/example_training_data.csv741.3 KB
- Fine_tuning/full_model_training_24-03-12.pyruns8.0 KB
- Fine_tuning/selected_abs_Figure_2-3_24-06-10.ipynb212.0 KB
- generate_antibodies.pyruns2.9 KB
- LICENSE11.1 KB
- MAGE_annotated_training_data.zip2183.8 KB
- Output_analysis/figure1_plots_24-06-10.ipynb324.5 KB
- Output_analysis/output_filtering_annotation.ipynb14.6 KB
- Output_analysis/RBD_1K_sequences_24-03-16.csv1589.2 KB
- Output_analysis/selected_abs_Figure_2-3_24-06-10.ipynb211.9 KB
- Output_analysis/selected_abs_for_testing.csv26.8 KB
- Output_analysis/selection_pipeline_24-03-16.ipynb11.1 KB
- README.md3.4 KB
- README.md1.6 KB