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Lggnn

Skill BioTender-max/awesome-bio-agent-skills/skills/neuroclaw/lggnn

Use this model doc whenever the user wants to run LG-GNN (Local-to-Global GNN) for fMRI phenotype prediction. LG-GNN is a PyG-based GNN with SABP (Self-Attention Brain Pooling) and mutual-information regularization. NeuroClaw adapts the original population-graph version to single-subject brain graphs.From its SKILL.md

Install
npx -y skills add BioTender-max/awesome-bio-agent-skills --skill lggnn

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LG-GNN Model Doc

Overview

LG-GNN (Local-to-Global GNN) 是一种针对脑疾病诊断的两阶段图神经网络。原始论文使用 Local_GNN 提取每个被试的脑图嵌入,再通过基于人口学信息构建的 Global_GNN 进行人群图分类。NeuroClaw 改造为单被试任务:保留 Local_GNN(含 SABP + 互信息正则化的创新组件),用 MLP head 替代人口图。

  • Paper: Zhang et al., 2022, "Local to Global Hierarchical Graph Neural Network for Brain Disorder Diagnosis",MICCAI
  • Official code: https://github.com/cnuzh/LG-GNN
  • NeuroClaw reimplementation: models/lggnn/(去除人口图依赖,单被试 PyG 流程)
  • Primary input: PyG Data graph(与 BrainGNN 共享数据格式)
  • Primary output: phenotype prediction + ROI 重要性(SABP perm)+ MI loss 辅助监督

Research use only.


NeuroClaw 实现要点

  1. 单被试改造:原版需要非影像表型数据构建人口图,NeuroClaw 仅保留 Local_GNN,用 MLP head 输出。
  2. SABP 池化:Self-Attention Brain Pooling,topk 选择 ROI + tanh(score) 加权,并产生互信息估计 mi 作为辅助 loss(论文权重 0.1,loss 取 loss - 0.1 * mi 鼓励高互信息)。
  3. PyG 2.7 兼容:原 torch_geometric.nn.pool.topk_pool 已重构,NeuroClaw 用 pool.select.topk + 内联 filter_adj。
  4. 任务统一接口:classification (nclass=N) 与 regression (nclass=1, task='regression') 一套代码。
  5. 数据复用:直接复用 BrainGNN 的 NeuroClawFCDataset,无需额外预处理。

Quick Start (NeuroClaw 内部)

前置条件

  • conda env: neuroclaw (Python 3.11)
  • 已有 data/braingnn_input/<atlas>/sub-*.pt 文件(与 BrainGNN 共享)

训练(分类,单 fold 冒烟测试)

python skills/lggnn/scripts/train_reference.py \
    --atlas aal_116 \
    --labels-csv data/hcp_gender_labels.csv \
    --fold 0 --n-epochs 10 --batch-size 16

训练(回归,HCP age)

python skills/lggnn/scripts/train_reference.py \
    --atlas schaefer_100_7net \
    --labels-csv data/hcp_age_labels.csv \
    --task regression --fold 0 --n-epochs 50

核心文件

文件作用
models/lggnn/net/lggnn.py模型定义:LocalGNN (GCN×2 + SABP + GCN) + MLP head
models/lggnn/scripts/data_adapter.py数据适配(薄封装复用 models.braingnn)
skills/lggnn/scripts/train_reference.pyK-fold CV 训练参考实现

模型架构

Input PyG Data (x=[N,N], edge_index, edge_attr, batch)
  -> GCNConv(N, 64) + ReLU
  -> GCNConv(64, 20) + ReLU
  -> SABP pool (ratio=0.5): topk_score + tanh weighted; 产生 mi_estimate
  -> GCNConv(20, 20) + ReLU
  -> 残差: pooled + conv3
  -> global_mean_pool
  -> MLP head: Linear(20 -> 64) + ReLU + Dropout + Linear(64 -> nclass)
Output: (logits, mi_loss)

关键训练参数

参数论文默认NeuroClaw 默认说明
--lr0.010.001论文用 0.01,NeuroClaw 与其他模型对齐用 0.001
--wd5e-55e-4权重衰减
--hidden-dim6464GCN 隐藏维度
--embed-dim2020SABP 后嵌入维度
--ratio0.90.5SABP keep ratio,论文 0.9,对齐 BrainGNN 用 0.5
--dropout0.20.3MLP head dropout
--mi-weight0.10.1MI loss 权重(注意:从 loss 中减去)
--n-epochs40050论文 400 ep,NeuroClaw 50 ep 与其他模型对齐

调试经验与注意事项

  1. MI loss 符号:原论文 loss = loss_cla - 0.1 * mi_loss(最大化 MI),NeuroClaw 保持相同符号约定。
  2. SABP 输出形状:池化后节点数变为 floor(ratio * N),注意 batch 后的 graph_emb 是 [B, embed_dim]。
  3. ratio 调参:论文 ratio=0.9(仅丢 10% ROI)需要 hgc=16;NeuroClaw 用 hgc=64 时 ratio=0.5 更稳定。
  4. PyG 2.7 兼容:旧版 topk_pool.topk/filter_adj 已移除,使用 pool.select.topk.topk 与内联 _filter_adj。
  5. MI 初始为 0:训练开始时 mi_estimate ≈ 0(因 joint 和 margin 分布相近),训练过程中应逐步变正。
  6. 数据复用:与 BrainGNN 共享 NeuroClawFCDataset,无需重复加载/缓存。

NeuroClaw 委托规则

  • ROI 生成和预处理:委托 fmri-skill
  • HCP 数据下载/编排:委托 hcpya-skill / hcpa-skill / hcpd-skill / hcpep-skill
  • 依赖检查:dependency-planner + conda-env-manager
  • 执行路由:claw-shell

执行前需明确计划确认。


Reference

  • Zhang Y, Zhan L, Cai W, Thompson P, Huang H. 2022. Local to Global Hierarchical Graph Neural Network for Brain Disorder Diagnosis. MICCAI.
  • Official repository: https://github.com/cnuzh/LG-GNN
  • NeuroClaw BrainGNN skill (共享数据格式): skills/brain_gnn/SKILL.md

Created At: 2026-05-19 01:30 HKT Last Updated At: 2026-05-19 01:30 HKT Author: chengwang96

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