agentsclimarketplace

Clinical

Skill BioTender-max/awesome-bio-agent-skills/skills/labclaw/clinical

A curated collection of AI agent skills for biomedical research, covering genomics, proteomics, single-cell analysis, clinical AI, and protein design.

Install
npx -y skills add BioTender-max/awesome-bio-agent-skills --skill clinical

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SKILL.md

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Clinical Research

Overview

Clinical study design, statistical analysis, and regulatory compliance for medical research.

Study Designs

DesignLevel of EvidenceBest For
RCTITreatment efficacy
Cohort (prospective)IIRisk factors, prognosis
Cohort (retrospective)IIIExposure-outcome associations
Case-controlIIIRare diseases, risk factors
Cross-sectionalIVPrevalence, correlations
Case report/seriesVNovel observations

Common Analyses

  • Survival analysis: Kaplan-Meier curves, Log-rank test, Cox regression
  • Diagnostic accuracy: Sensitivity, specificity, ROC curve, AUC
  • Meta-analysis: Fixed/random effects, forest plot, heterogeneity (I-squared)
  • Propensity score matching: For observational study confounding
  • Nomogram: Predictive model visualization for clinical use

Sample Size Calculation

  • Define: alpha (usually 0.05), power (usually 0.80), effect size, outcome type
  • Tools: G*Power, R pwr package, Python statsmodels
  • Report: formula used, assumptions, expected dropout rate

Regulatory Compliance

  • IRB/Ethics committee: Required for all human subjects research
  • Informed consent: Written, voluntary, comprehensive
  • ClinicalTrials.gov: Registration before enrollment (ICMJE requirement)
  • GDPR/HIPAA: Data privacy for patient information
  • GCP (Good Clinical Practice): ICH E6 guidelines

Reporting Guidelines

GuidelineStudy Type
CONSORTRandomized controlled trials
STROBEObservational studies
PRISMASystematic reviews / meta-analyses
STARDDiagnostic accuracy
TRIPODPrediction models
SPIRITStudy protocols

Keep looking

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