Dilirank

Skill BioTender-max/awesome-bio-agent-skills/skills/drugclaw/dilirank

Query the DILIrank/FDA Liver Toxicity Knowledge Base (LTKB). Use whenever the user asks about drug-induced liver injury (DILI) risk, hepatotoxicity classification, or wants to look up any drug (by name, LTKB ID, or DILIst ID) in the DILIrank or DILIst datasets.From its SKILL.md

Install

npx -y skills add BioTender-max/awesome-bio-agent-skills --skill dilirank

Assembled from the repository path, not quoted from the project. Check it against their README if it does not work.

One thing to look at

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SKILL.md

2.2 KB, 577 tokens by cl100k_base, as published. Nobody here has run it

LTKB Query Skill

Search FDA LTKB records (DILIrank 2.0 + DILIst) by any entity. Auto-detects type by pattern:

Input Pattern	Detected As	Searched In
`LT00040`	LTKB ID	DILIrank only
`2` (digits)	DILIst ID	DILIst only
anything else	drug name	both datasets (substring)

Datasets

DILIrank 2.0 — 1,036 FDA-approved drugs ranked by DILI concern:

vDILI-Concern	Meaning
vMOST-DILI-concern	Strong evidence of causing DILI
vLess-DILI-concern	Some evidence of causing DILI
vNo-DILI-concern	No credible evidence
vAmbiguous-DILI-concern	Conflicting/insufficient evidence

Columns: LTKBID, CompoundName, SeverityClass, LabelSection, vDILI-Concern, Comment

DILIst — 1,279 drugs classified by DILI severity:

Classification	Meaning
1	DILI-positive
0	DILI-negative

Columns: DILIST_ID, CompoundName, DILIst Classification, Routs of Administration

API

Function	Input	Returns
`load_all(rank_path, list_path)`	Excel paths	`{"dilirank": [...], "dilist": [...]}`
`search(data, entity)`	data dict + entity string	`{"entity", "type", "dilirank": [], "dilist": []}`
`search_batch(data, entities)`	data dict + list of strings	`{entity: search_result}`
`summarize(result, entity)`	search result + label	compact text
`to_json(result)`	search result	JSON string

Usage

See if __name__ == "__main__" block in 48_LTKB.py for runnable examples covering: drug name, LTKB ID, DILIst ID, batch search, and JSON output.

Data

Source: FDA LTKB — https://www.fda.gov/science-research/bioinformatics-tools/liver-toxicity-knowledge-base-ltkb
Files: Drug Induced Liver Injury Rank (DILIrank 2.0) Dataset FDA.xlsx, DILIst Supplementary Table.xlsx
Path: DATA_DIR variable in 48_LTKB.py

What ships with it: 5 files

12.1 KB alongside SKILL.md, 4 of them executable

dilirank_skill.pyruns2.4 KB
example.pyruns7.8 KB
__init__.pyruns138 B
README.md979 B
retrieve.pyruns835 B