Model evaluation
Agent Skills for medical research — literature search, reporting-guideline & citation checks, statistics, publication figures, submission. Works with Claude Code, Codex, Cursor & GitHub Copilot. Built by a physician-researcher, tested on real publications. MIT.
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What its author says it does
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Compute and report task-correct held-out metrics for a trained medical-imaging model — segmentation (Dice plus a boundary metric such as HD95 or NSD, per structure), classification (AUROC plus AUPRC and sensitivity/specificity with bootstrap CIs at the deployment prevalence), detection (FROC or mAP with a stated IoU criterion), interactive/promptable segmentation (the interaction-count, convergence, and per-case-time axes a static Dice omits), or generative/synthesis image evaluation (similarity plus the downstream-task efficacy similarity alone cannot establish) — plus calibration and subgroup slices. Emits a per-case results table that analyze-stats turns into publication tables, and gates the metric choice against Metrics Reloaded, CLAIM 2024, and Park et al. 2024 (no pixel accuracy for segmentation, no bare accuracy under imbalance, no static Dice for an interactive method, no similarity-only claim for a generative model). Numbers come only from executed code, never hand-typed.
SKILL.md
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Model-Evaluation Skill
Purpose
This skill makes a medical-imaging model's held-out evaluation task-correct and honest: the right metric for the task and the prevalence, with uncertainty, calibration, and subgroup performance. It emits a per-case metric table that the publication statistics build on, and gates the metric choice against Metrics Reloaded (Maier-Hein & Reinke et al., Nat Methods 2024) and CLAIM 2024.
It sits between /model-validation (which audits the split / design) and /analyze-stats (which owns
the comparative inference). It computes the imaging-specific per-case metrics (surface distances, FROC,
ECE of a softmax head); /analyze-stats owns DeLong / NRI / IDI / decision curves / MRMC. Like
/analyze-stats, it generates and executes code on your predictions — numbers are never hand-typed.
When to use
- You have held-out predictions + ground truth and need task-correct metrics with CIs, calibration, and subgroup slices, plus a per-case table for the manuscript statistics.
When NOT to use
- Auditing the validation design / leakage →
/model-validation. - DeLong / NRI / IDI / decision curves / MRMC reader study →
/analyze-stats. - Building / training the model →
/model-scaffold; LLM / MLLM →/mllm-eval. - Figure rendering →
/make-figures.
Workflow
Phase 1 — Fix the analysis unit and the task
State the task (segmentation / classification / detection / interactive / generative) and the analysis unit the metric must respect (per-patient vs per-lesion vs per-image). A per-lesion metric must not be reported as per-patient.
Phase 2 — Compute task-correct metrics
Generate evaluation code that computes, on the held-out predictions:
- segmentation: Dice/IoU and a boundary metric (HD95 / NSD), per structure not only a global mean, with bootstrap 95% CIs.
- classification: AUROC and AUPRC with bootstrap CIs, sensitivity/specificity, and PPV/NPV at the deployment prevalence (not a balanced set).
- detection: FROC / mAP with the IoU match criterion stated.
- interactive / promptable segmentation (SAM2 / MedSAM2 / nnInteractive): the segmentation
metrics above plus the interaction axis — Dice-vs-interactions / number-of-clicks (NoC) to a
target threshold, initial-vs-converged (or peak) Dice, and per-case interaction/inference time
(see the metric guide; the study design is in
/design-study+/model-validation). - generative / synthesis (image generation or modification): full-reference similarity
(MSE/RMSE/PSNR/SSIM) or no-reference quality (SNR/CNR, standardized visual scores), plus a
downstream-task evaluation — image quality is not clinical utility (Park et al., Radiol Med 2024).
For multiclass classification, state the aggregation scheme (one-vs-rest / macro / micro /
pairwise / Obuchowski); time-to-event discrimination (Harrell's C, time-dependent ROC) is handed
to
/analyze-stats. Add calibration (reliability diagram / ECE) and subgroup slices (the Model Card Factors). See${CLAUDE_SKILL_DIR}/references/metric_guide.md. Emit a per-case CSV for/analyze-stats.
Phase 3 — Gate the metric choice (deterministic)
python3 ${CLAUDE_SKILL_DIR}/scripts/check_metric_reporting.py \
--report results.md --task segmentation|classification|detection|interactive|generative --strict
PIXEL_ACCURACY_SEG / NO_BOUNDARY_METRIC / ACCURACY_ONLY / DETECTION_METRIC_MISSING must be zero.
Phase 4 — Hand off
The per-case table → /analyze-stats (DeLong / NRI / IDI / decision curves, publication tables);
figures → /make-figures; the numbers + subgroup performance → /model-card; Methods/Results →
/write-paper; compliance → /check-reporting.
Anti-Hallucination
- Never fabricate a metric value. Every number comes from executed code on the supplied predictions; if predictions or ground truth are missing, say so and stop — do not invent a result.
- Never report pixel/voxel accuracy for segmentation or bare accuracy under imbalance — the gate flags these; report Dice + a boundary metric, or AUROC + AUPRC with CIs.
- Never report a per-lesion metric as if it were per-patient — respect the analysis unit.
- If a metric definition or its CI method is uncertain, flag
[VERIFY]and ask.
Deterministic gate
scripts/check_metric_reporting.py — flags a task-metric mismatch / missing uncertainty (stdlib,
network-free). Reproducible challenge: bash ${CLAUDE_SKILL_DIR}/scripts/metric_reporting_challenge/verify.sh.
Reference Files
Load on demand (keep SKILL.md short):
${CLAUDE_SKILL_DIR}/references/metric_guide.md— operational checklist: the task-correct metric per task (segmentation Dice + HD95/NSD per structure; classification AUROC + AUPRC + sens/spec at deployment prevalence; detection FROC/mAP with a stated IoU), plus calibration, subgroup slices, run-variance, and the per-case CSV hand-off.${CLAUDE_SKILL_DIR}/references/metric_selection_grounding.md— the standards grounding behind those choices: the Metrics Reloaded task-fingerprint principle, why each metric pairing is required, calibration vs discrimination, disaggregated reporting, and the CLAIM 2024 reporting-fit map (/check-reportingowns the item audit).
Boundaries
model-validation (design) -> model-evaluation (this skill: per-case task-correct metrics + CIs)
-> analyze-stats (DeLong / NRI / IDI / decision curves, publication tables) -> make-figures
-> model-card (numbers + subgroup) -> write-paper + check-reporting