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Tmb msi calculator

Skill a5c-ai/babysitter/library/specializations/domains/science/bioinformatics/skills/tmb-msi-calculator

Tumor mutation burden and microsatellite instability calculation skill for immunotherapy biomarkersFrom its SKILL.md

Install
npx -y skills add a5c-ai/babysitter --skill tmb-msi-calculator

Assembled from the repository path, not quoted from the project. Check it against their README if it does not work.

SKILL.md

1.3 KB, 151 tokens by cl100k_base, as published. Nobody here has run it

TMB-MSI Calculator Skill

Purpose

Calculate tumor mutation burden and microsatellite instability for immunotherapy biomarker assessment.

Capabilities

  • TMB calculation from VCF
  • MSI status determination
  • Neoantigen prediction
  • HLA typing integration
  • Biomarker thresholds
  • Clinical report generation

Usage Guidelines

  • Calculate TMB with appropriate normalization
  • Determine MSI status accurately
  • Predict neoantigens for immunotherapy
  • Apply clinical thresholds for reporting
  • Generate actionable reports
  • Document methodology and thresholds

Dependencies

  • TMBcat
  • MSIsensor2
  • MANTIS

Process Integration

  • Tumor Molecular Profiling (tumor-molecular-profiling)

What ships with it

Read from the repository

Just SKILL.md. No reference files, no scripts.

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